iron sprinkles - iron deficiency supplement
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RESEARCH AND DEVELOPMENT  
 
Pakistan

It has been estimated that diarrheal illnesses account for 12,600 deaths each day in children in Asia, Africa, and Latin America while pre-school children spend 35 to 70 days per year with diarrhea. Although, oral rehydration therapy has reduced diarrhea-related mortality by 50%, its affect has plateaud. To further decrease this burden malnutrition and immunity needs to be targeted. Sprinkles Supplefer Plus is unique in that micronutrients such as iron, zinc, Vitamin A and C, together with a probiotic can be formulated into the sachet to prevent common micronutrient deficiencies as well as diarrhea.

We investigated the effect of zinc and a heat-killed strain of probiotic L. acidophilus provided as micronutrient Sprinkles on diarrhea morbidity in infants. This community-based, double-blind, placebo-controlled trial took place in an urban slum of Karachi, Pakistan. 75 infants at high-risk for diarrhea-related-mortality identified as: (a) age between 6 to12 months; and (b) history of 1 episode of diarrhea in the past 2 weeks, were randomly allocated to receive: (a) Sprinkles; or (b) Sprinkles + L.acidophilus (Sprinklesplus); or (c) Placebo, daily for 2 months. Primary outcome was longitudinal prevalence of diarrhea (number of diarrhea-days per observed child-days); a surrogate measure for mortality. Other outcome measures were child-days of fever, hemoglobin, serum ferritin and plasma zinc concentrations. Longitudinal prevalence of diarrhea was significantly less (p<0.05) in the Sprinkles group (18 ± 20% child-days) than Sprinklesplus (34 ± 30% child-days) and placebo groups (26 ± 20% child-days). A similar trend was observed for child-days of fever. Micronutrients formulated as Sprinkles apparently potentiated immunity to impact morbidity from diarrhea and other infections. However, L.acidophilus seemed to have a negative effect.

This study was supported by the HJ Heinz Foundation, Inst Rosell Lellamand and Canadian Institutes of Health Research.


Pakistan Frontier Primary Health

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Links:
Canadian International Development Agency (CIDA) |  Centers for Disease Control and Prevention (CDC) |  Food and Agriculture Organization (FAO) |  Health Canada |  The Hospital for Sick Children |  The Hunger Site, Sight and Life |  The International Development Research Center (IDRC) |  International Life Sciences Institute (ILSI)  |  Micronutrient Initiative (MI) |  The Pan American Health Organization (PAHO) |  United Nations Children’s Fund (UNICEF) |  University of Toronto |  U.S. Agency for International Development (USAID) |  World Health Organization (WHO) |  Canadian Institutes of Health Research. | 


 

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